J. Skarżewski

Professor Jacek Skarżewski
Head of Department

Room: 322 / A2
Phone: +48713202464

1972 M.Sc. Chemistry, Wrocław University of Technology
1975     Ph.D. Chemistry, (with Prof. Zofia Skrowaczewska), Wrocław University of Technology
1987   Habilitation
2001   Full Professor

Fellowships:
1976-1978  Postdoc, Gunma University, Kiryu, Japan
1984 Research visit, Universitat der Stuttgart, Germany

Current research interests:
The main effort is in the area of organic synthesis with particular concern of application of new catalytic reactions and reagents.  Currently conducted research including graduate and undergraduate projects is aimed at synthesis and application of chiral ligands in transition metal-catalyzed enantioselecive transformations.  Additional branch deals with the synthesis of alkaloid derivatives and their organocatalytic applications.

Recent papers
1. Boratyński, P.J., Kraj, A., Skarżewski, J.: “Unusual oxidative Smiles reaction of quinine 1,10-phenanthro-2-yl-thioether with SO2 extrusion.” Phosphorus, Sulfur and Silicon and the Related Elements 2017, 192, 227-230.
2. Kamińska, K., Wojaczyńska, E., Skarżewski, J., Kochel, A., Wojaczyński, J.: “Application of sulfonyl chlorides and chiral amines in the efficient synthesis of nonracemic sulfinamides.” Tetrahedron Asymmetry 2017, 28, 561-566.
3. Küppers, J., Schulz-Fincke, A.C., Palus, J., Giurg, M., Skarżewski, J., Gütschow, M.: “Convergent synthesis of two fluorescent ebselen-coumarin heterodimers.” Pharmaceuticals 2016, 9, –.
4. Zielińska-Błajet, M., Boratyński, P.J., Sidorowicz, Ł., Skarżewski, J.: “Simple approach to modular chiral scaffolds: Binding functional sulfur nucleophiles to Cinchona alkaloids.” Tetrahedron 2016, 72, 2643-2648.
5. Wojaczyńska, E., Kamińska, K., Wojaczyński, J., Skarżewski, J.: “Chiral pyrrolidine thioethers and 2-azanorbornane derivatives bearing additional nitrogen functions. Enantiopure ligands for palladium-catalyzed Tsuji-Trost reaction.” Arkivoc 2016, 2017, 162-172.
6. Siedlecka, R., Wal, R., Skarżewski, J.: “One step amidine formation via reductive cyclization of (2-pyridyl)-β-nitriles.” Tetrahedron 2016, 72, 6678-6683.
7. Wojaczyńska, E., Skarżewski, J., Sidorowicz, Ł., Wieczorek, R., Wojaczyński, J.: “Zinc complexes formed by 2,2′-bipyridine and 1,10-phenanthroline moieties combined with 2-azanorbornane: Modular chiral catalysts for aldol reactions.” New Journal of Chemistry 2016, 40, 9795-9805.
8. Boratyński, P.J., Nowak, A.E., Skarżewski, J.: “New Chiral Benzimidazoles Derived from 1,2-Diaminocyclohexane.” Synthesis (Germany) 2015, 47, 3797-3804.
9. Wąsińska, M., Korczewska, A., Giurg, M., Skarżewski, J.: “Improved Protocol for Mononitration of Phenols with Bismuth(III) and Iron(III) Nitrates.” Synthetic Communications 2015, 45, 143-150.
10. Zielińska-Błajet, M., Boratyński, P.J., Palus, J., Skarżewski, J.: “Chiral benzisoselenazolones: Conformational analysis based on experimental and DFT calculated 77Se NMR.” Tetrahedron 2013, 69, 10223-10229.
11. Zielińska-Błajet, M., Skarżewski, J.: “Stereoselective dithiophosphorylation of cinchona alkaloids: Easy approach to prospective chiral ligands and organocatalysts.” Phosphorus, Sulfur and Silicon and the Related Elements 2013, 188, 1811-1818.
12. Boratyński, P.J., Skarżewski, J.: “Diastereoselective Corey-Chaykovsky 9-epoxymethylation of cinchona alkaloids: Access to chiral scaffolds with diverse functionalities.” Journal of Organic Chemistry 2013, 78, 4473-4482.
13. Kowalczyk, R., Nowak, A.E., Skarżewski, J.: “Organocatalytic asymmetric addition of aliphatic thiols to nitro olefins and nitrodienes.” Tetrahedron Asymmetry 2013, 24, 505-514.
14. Wojaczyńska, E., Turowska-Tyrk, I., Skarżewski, J.: “Novel chiral bridged azepanes: Stereoselective ring expansion of 2-azanorbornan-3-yl methanols.” Tetrahedron 2012, 68, 7848-7854.
15. Boratyński, P.J., Turowska-Tyrk, I., Skarżewski, J.: “Synthetic approaches to 9-arylated Cinchona alkaloids: Stereoselective addition of Grignard reagents to cinchonanones and hydroxylation of 9-phenylcinchonanes.” Tetrahedron Asymmetry 2012, 23, 876-883.
16. Boratyński, P.J., Skarżewski, J., Sidorowicz, Ł.: “Stereochemistry of hydrophosphonylation of 9-aminoquinine Schiff bases.” Arkivoc 2012, 2012, 204-215.
17. Nowak, A.E., Wojaczyńska, E., Skarewski, J.: “Enantiopure trans-1-amino-2-(arylsulfanyl)cyclohexanes: Novel chiral motifs for ligands and organocatalysts.” Tetrahedron Asymmetry 2011, 22, 1687-1691.
18. Bkowicz, J., Skarżewski, J., Turowska-Tyrk, I.: “Photo-induced structural changes in two crystal forms with different numbers of independent molecules.” CrystEngComm 2011, 13, 4332-4338.
19. Zielińska-Błajet, M., Skarżewski, J.: “Enantioselective Henry reaction catalyzed by copper(II) – Cinchona alkaloid complexes.” Tetrahedron Asymmetry 2011, 22, 351-355.
20. Sidorowicz, L., Skarżewski, J.: “Easy access to 9-epimers of cinchona alkaloids: One-pot inversion by mitsunobu esterification-saponification.” Synthesis 2011, , 708-710.
21. Wojaczyńska, E., Zielińska-Błajet, M., Turowska-Tyrk, I., Skarżewski, J.: “Sulfoxides derived from Cinchona alkaloids – Chiral ligands in palladium-catalyzed asymmetric allylic alkylation.” Tetrahedron Asymmetry 2010, 21, 853-858.
22. Boratyński, P.J., Skarżewski, J.: “New functional derivatives of 9-phenylquinine.” Synthesis 2009, , 3113-3119.
23. Kowalczyk, R., Skarżewski, J.: “Asymmetric nitroaldol reaction catalyzed by copper-diamine complexes: selective construction of two contiguous stereogenic centers.” Tetrahedron Asymmetry 2009, 20, 2467-2473.
24. Zielińska-Błajet, M., Skarżewski, J.: “New chiral thiols and C2-symmetrical disulfides of Cinchona alkaloids: ligands for the asymmetric Henry reaction catalyzed by CuII complexes.” Tetrahedron Asymmetry 2009, 20, 1992-1998.
25. Wojaczyńska, E., Skarżewski, J.: “An effective deracemization of trans-1,2-bis (phenylsulfenyl)cyclohexane.” Phosphorus, Sulfur and Silicon and the Related Elements 2009, 184, 1323-1331.
26. Kowalczyk, R., Kwiatkowski, P., Skarżewski, J., Jurczak, J.: “Enantioselective nitroaldol reaction catalyzed by sterically modified salen-chromium complexes.” Journal of Organic Chemistry 2009, 74, 753-756.
27. Kowalczyk, R., Sidorowicz, Ł., Skarżewski, J.: “Asymmetric Henry reaction catalyzed by chiral secondary diamine-copper(II) complexes.” Tetrahedron Asymmetry 2008, 19, 2310-2315.
28. Boratyński, P.J., Turowska-Tyrk, I., Skarżewski, J.: “Stereoselective C9 carbon-carbon couplings of quinine: Synthesis and conformational analysis of new C2-symmetric dimers.” Journal of Organic Chemistry 2008, 73, 7357-7360.
29. Wojaczyńska, E., Skarżewski, J.: “Novel C2-symmetric chiral ligands: enantioselective transformation of cyclic 1,2-diols into 1,2-bis(phenylsulfenyl) and 1,2-bis(phenylselenyl) derivatives.” Tetrahedron Asymmetry 2008, 19, 593-597.
30. Boratyński, P.J., Turowska-Tyrk, I., Skarżewski, J.: “Stereoselective C9 arylation and vinylation of Cinchona alkaloids.” Organic Letters 2008, 10, 385-388.
31. Kowalczyk, R., Skarżewski, J.: “Selective nucleophilic substitution using pyrazolate anions: Easy approach to modular chiral ligands with complexing pyrazole moieties.” Polish Journal of Chemistry 2007, 81, 1987-1999.
32. Kowalczyk, R., Sidorowicz, Ł., Skarżewski, J.: “Asymmetric nitroaldol reaction catalyzed by a chromium(III)-salen system.” Tetrahedron Asymmetry 2007, 18, 2581-2586.
33. Zielińska-Błajet, M., Siedlecka, R., Skarżewski, J.: “Chiral phenylselenyl derivatives of pyrrolidine and Cinchona alkaloids: nitrogen-selenium donating ligands in palladium-catalyzed asymmetric allylic alkylation.” Tetrahedron Asymmetry 2007, 18, 131-136.
34. Drewnowski, T., Leśniak, S., Mlostoń, G., Siedlecka, R., Skarżewski, J.: “Studies on the flash vacuum thermolysis of thiones of selected N-, O-, and S-heterocycles.” Helvetica Chimica Acta 2006, 89, 991-999.
35. Kowalczyk, R., Skarżewski, J.: “O-Methylatrolactic acid as a new reagent for determination of the enantiomeric purity and absolute configuration of chiral alcohols and amines.” Tetrahedron Asymmetry 2006, 17, 1370-1379.
36. Zielińska-Błajet, M., Kucharska, M., Skarżewski, J.: “Simple enantiospecific synthesis of sulfides of Cinchona alkaloids.” Synthesis 2006, , 1176-1182.
37. Zielinska-Błajet, M., Kowalczyk, R., Skarżewski, J.: “Ring-closure reactions through intramolecular substitution of thiophenoxide by oxygen and nitrogen nucleophiles: Simple stereospecific synthesis of 4,5-dihydroisoxazoles and 4,5-dihydropyrazoles.” Tetrahedron 2005, 61, 5235-5240.
38. Kowalczyk, R., Skarżewski, J.: “Regioselective synthesis of optically active (pyrazolyl)pyridines with adjacent quaternary carbon stereocenter: Chiral N,N-donating ligands.” Tetrahedron 2005, 61, 623-628.